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450 West Drive
Chapel Hill, NC
University of North Carolina, Chapel Hill
The Emanuele Lab studies cell cycle regulation using systematic technologies and traditional cell, molecular and biochemical techniques.
Today was a big day in the lab. Our first graduate student, Allie Mills, successfully defended her dissertation to the Department of Pharmacology. She delivered a fantastic seminar to all of those in attendance. Congrats Allie and great job.
Allie and Mike, post-defense
On monday (12/18/17) we celebrated the holiday season with lunch out at City Kitchen and then all went to see the new Star Wars movie (The Last Jedi).
From left: Mike, Xianxi, Allie, Jen, Ana, Thomas, Anthony and Taylor
Great job Anthony for being awarded "Best Poster" at the 2017 UNC Lineberger Cancer Center scientific retreat.
Congratulations to Raj Choudhury on winning the UNC Lineberger Cancer Center Pagano Award in recognition of your paper describing a ubiquitin signaling circuit involved in regulation cell cycle entry. Read Raj's paper here.
In this exciting study, featured as the journals cover article, Allie established a novel connection between NUSAP1, a microtubule binding protein and substrate of the ubiquitin system, and a mitotic SUMO ligase. Read her article here
A long standing question is how the oncogenic kinase AKT promotes cell cycle progression. This study shows that Cyclin F, a non-canonical Cyclin, and substrate receptor for the SCF family of ubiquitin ligases, is a bona fide AKT substrate. This connects oncogenic AKT signaling, which is recurrently activated in many cancers, to control of the core cell cycle oscillator. This study was a collaboration with out colleagues at UNC in the Liu lab. Read about it here
This paper describes a paradoxical relationship between the cell cycle transcription factor FoxM1 and a Cul4-based ubiquitin ligase. FoxM1 is recurrently activated in aggressive breast and ovarian cancers, and this study shows that VprBP, a substrate receptor for Cul4, controls both the degradation and activation of FoxM1. Moreover, we showed that VprBP is overexpressed in high-grade serous ovarian tumors, potentially contributing to FoxM1 activation in malignancy. This study was a collaborative efforts with our colleauges at UNC, in the Bowers and Bae-Jump labs. Read more here.
Raj just accepted a position at Glaxo-Smith Kline in the Philadelphia area. We will miss you. Good luck. Enjoy the cheesesteaks and pretzels!
This paper describes a feedback circuit that controls cell cycle entry. It centers on two crucial cell cycle ubiquitin ligases, the SCF and APC/C and shows that they coordinately control each other during progression through the cell cycle. Read more here
